Investigating the effects of BAG3 knockdown on the cytotoxicity of the anticancer drug Laromustine

Part of the Biochemistry Commons Colby College theses are protected by copyright. They may be viewed or downloaded from this site for the purposes of research and scholarship. Reproduction or distribution for commercial purposes is prohibited without written permission of the author. Chemistry: Biochemistry with a minor in Creative Writing. She was also very involved with the club Colby Dancers, serving as President for her last two years at Colby. In the fall of 2013, she will matriculate into the Integrated Studies Program as a first-year PhD candidate in the Tufts University Sackler School of Graduate Biomedical Sciences. Acknowledgements I would like to thank Professor Kevin P. Rice for being an exceptional instructor and a wonderful research mentor for my entire four years at Colby College. Working for the Rice Lab has been so rewarding and transformative, and I count it as one of my most valuable Colby experiences. I would also like to thank Professor Ethan Kohn for instructing me on the biological basis of cancer and for his guidance and counsel in reviewing my thesis. I thank Tara Kraus and Amy Poulin for their technical and administrative support; the Rice Lab wouldn't run nearly as smoothly without them. I'm also very appreciative for my fellow lab members, as their advice and enthusiasm for science research have been very supportive and encouraging as I have completed my thesis work. Also, I thank Edmund Klinkerch for the synthesis of Laromustine, 90CE, and 101MDCE. Lastly, this work was made possible by grants from the National Center